Host heme oxygenase-1: Friend or foe in tackling pathogens?
Identifieur interne : 000A03 ( Main/Exploration ); précédent : 000A02; suivant : 000A04Host heme oxygenase-1: Friend or foe in tackling pathogens?
Auteurs : Nisha Singh [Inde] ; Zeeshan Ahmad [Inde] ; Navin Baid [Inde] ; Ashwani Kumar [Inde]Source :
- IUBMB life [ 1521-6551 ] ; 2018.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Maladies transmissibles.
- enzymologie : Maladies transmissibles.
- métabolisme : Heme oxygenase-1.
- étiologie : Maladies transmissibles.
- Animaux, Antioxydants, Humains, Maladies transmissibles, Oxydoréduction, Stress oxydatif.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Heme Oxygenase-1.
- chemical : Antioxidants.
- enzymology : Communicable Diseases.
- etiology : Communicable Diseases.
- pathology : Communicable Diseases.
- therapy : Communicable Diseases.
- Animals, Humans, Oxidation-Reduction, Oxidative Stress.
Abstract
Infectious diseases are a major challenge in management of human health worldwide. Recent literature suggests that host immune system could be modulated to ameliorate the pathogenesis of infectious disease. Heme oxygenase (HMOX1) is a key regulator of cellular signaling and it could be modulated using pharmacological reagents. HMOX1 is a cytoprotective enzyme that degrades heme to generate carbon monoxide (CO), biliverdin, and molecular iron. CO and biliverdin (or bilirubin derived from it) can restrict the growth of a few pathogens. Both of these also induce antioxidant pathways and anti-inflammatory pathways. On the other hand, molecular iron can induce proinflammatory pathway besides making the cellular environment oxidative in nature. Since microbial infections often induce oxidative stress in host cells/tissues, role of HMOX1 has been analyzed in the pathogenesis of number of infections. In this review, we have described the role of HMOX1 in pathogenesis of bacterial infections caused by Mycobacterium species, Salmonella and in microbial sepsis. We have also provided a succinct overview of the role of HMOX1 in parasitic infections such as malaria and leishmaniasis. In the end, we have also elaborated the role of HMOX1 in viral infections such as AIDS, hepatitis, dengue, and influenza. © 2018 IUBMB Life, 70(9):869-880, 2018.
DOI: 10.1002/iub.1868
PubMed: 29761622
Affiliations:
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Recent literature suggests that host immune system could be modulated to ameliorate the pathogenesis of infectious disease. Heme oxygenase (HMOX1) is a key regulator of cellular signaling and it could be modulated using pharmacological reagents. HMOX1 is a cytoprotective enzyme that degrades heme to generate carbon monoxide (CO), biliverdin, and molecular iron. CO and biliverdin (or bilirubin derived from it) can restrict the growth of a few pathogens. Both of these also induce antioxidant pathways and anti-inflammatory pathways. On the other hand, molecular iron can induce proinflammatory pathway besides making the cellular environment oxidative in nature. Since microbial infections often induce oxidative stress in host cells/tissues, role of HMOX1 has been analyzed in the pathogenesis of number of infections. In this review, we have described the role of HMOX1 in pathogenesis of bacterial infections caused by Mycobacterium species, Salmonella and in microbial sepsis. We have also provided a succinct overview of the role of HMOX1 in parasitic infections such as malaria and leishmaniasis. In the end, we have also elaborated the role of HMOX1 in viral infections such as AIDS, hepatitis, dengue, and influenza. © 2018 IUBMB Life, 70(9):869-880, 2018.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Singh, Nisha" sort="Singh, Nisha" uniqKey="Singh N" first="Nisha" last="Singh">Nisha Singh</name></noRegion><name sortKey="Ahmad, Zeeshan" sort="Ahmad, Zeeshan" uniqKey="Ahmad Z" first="Zeeshan" last="Ahmad">Zeeshan Ahmad</name><name sortKey="Baid, Navin" sort="Baid, Navin" uniqKey="Baid N" first="Navin" last="Baid">Navin Baid</name><name sortKey="Kumar, Ashwani" sort="Kumar, Ashwani" uniqKey="Kumar A" first="Ashwani" last="Kumar">Ashwani Kumar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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